If it was me, it would greatly depend on the location. Is it a tourist area? seasonal? Is the rental demand being met? Oversupply? etc.
Talk to some real estate agents that sell vacation homes and property managers that manage them. Find out how many weeks on average homes of your type rent and what they rent for.
Then you can compare using the average rental and a property managment company to do the cleaning, getting the keys to the renter, etc. and see how it compares vs. just renting it to a full time resident.
I would not try to do a vacation rental myself unless I was in the same neighborhood or close. You have to meet someone on site every week you rent it and it takes a lot to time to manage the reservation system. If you can find a property manager who also handles the reservations and it makes you more than a full time renter (with an estimated vacancy for both) then I think you have potential to do well. Otherwise the hassle would be too much for me.
Also, you should figure the wear and tear will be higher on a vacation rental home. I would probably want to expect to make at least 10% more before switching. However, if you have a good manager and strategies for maintaining occupany in off season you can do really well.