Yes you will feel motion. I just finished my first ever cruise and I have had motion issues ever since suffering 2 concussions a dozen or so years ago. I noticed the motion the first night, a nice calm night at sea. It didn't make me sick, but I felt it in my head. Our night from Grand Cayman to Cozumel was bad. Very windy and large swells and the boat at a good list. It was a tough night to move around.
But through it all, it wasn't enough to make me sick or disable me.
I would recommend meds, patches, or wristbands, whatever works for you. The motion might not bother you at all, but take it just in case. If you forget to bring something or lose it, you can buy meds or wriststraps in the midship shops, or *TIP* go to customer service and ask for it. We received dramamine for free.
So there's no way to know if it will affect you or not until you get there, but be prepared for a pretty continuous state of motion.