I don't think I've heard from anyone doing it yet.
As far as the trip is concerned, the Fairmont Hotel is the 'Grand Dame' of San Francisco. I've never stayed there, but I've eaten there, and it was marvelous.
You're certainly seeing a lot for a long weekend. Lucasfilms and the Walt Disney Family Museum are pretty unique, and you get to see Fisherman's Wharf and the Presidio and Angel Island. Plus the side trip to Napa and Muir Woods sounds wonderful, too (I've been to both, and they're lovely!)
It's obviously a much shorter trip than you're used to, but I think they pack a lot into that short amount of time. I've been toying with doing it the next time I'm in California.
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