We drive down from Delaware once a year. After 5 trips, I finally have worked out the best way for my family of 5 to drive down. On the last trip, I left Delaware at 11pm Friday night. I only stopped for bathroom breaks or if I needed a quick breather. I get into Exit 164 in SC around 7am depending on weather, traffic, etc. We eat at the Cracker Barrel and fill the tank. On the road again and in Disney by 3pm. The kids sleep most of the way and it is a very smooth ride. We pack lots of snacks and drinks for the last few hours. Mostly the kids just watch a few movies and the time is passed.
Have fun !
Mike