If you have ANY thoughts of stopping overnight, be prepared that many others may have the same thought and a hotel may or may not be available. I'm sure that this may no longer be the case, but when we last drove from Michigan in 2010, we made hotel reservations for the trip home. We had 6 people (4 drivers) but we knew we were going to stop overnight. I can't remember where we made the reservation, but while we waited to check in (mobile check in wasn't a thing back then), we saw multiple people get turned away due to no vacancy. We heard many lamenting that they would "have to keep going" and that they'd been "checking for miles" because everything was full.
When we drive, we leave in the afternoon, drive 4-5 hours and then stop for the night (usually southern Ohio/Northern KY) and then get up and make the remaining drive the next day. If we have time, we take it easy and stop around Lake City, FL and stay there for the night and then make the 2-hr or so drive to Orlando on the third morning and arrive rested and ready to go. We have driven 4 times and we have done it both ways.