We're a couple hours west of you in Johnstown, probably drove the trip a dozen times over the past four years before flying the last couple of trips. We always enjoyed the drive, and after experimenting with different routes, stops, etc., settled in on driving to Florence, SC the first day and then on to Disney the 2nd day for our trips.
Florence has a couple of Marriot properties right off the exit, I usually have Marriot points to use so we either stay at the Residence Inn or Springhill Suites, they are right next to each other. There are restaurants very close and it's literally a mile from the exit.
Our normal routine would be to get on the road at 8 - 8:30 in the morning, stop for a sit-down lunch, say an hour to break up the trip, and get to Florence at 5:00 - 5:30, eat, swim, and bed. The next day if we left at 8 - 8:30, stop again for lunch, we'd be in Disney by 3:30 - 4:00. We'd repeat the route on the way home, it was really an easy trip and we actually enjoyed the time to talk, could get there faster by eating fast food on the way down but we always enjoyed taking a break for lunch.