We have older kids - teens with lots of hair stuff - but with your 2 cute little girls this is what I would do it I were you.
1) not sure of your resort - 214 sq feet at values, 320 sq feet at moderates, and 360 or more sq feet at deluxes ...... the more space in the room -> the easier to organize.
Our hints:
over the door shoe holder (or hang in closet - bring some zip lock ties and a scissor to remove the zip lock ties)
we get a cheap $1 store sand buckets, different color for each kid, (small-medium size) to hold each of our kids stuff - and I mean stuff - hair brushes, hair ties, cell phones, ipods, digital cameras, makeup, hair goo,,,, and what ever floats their boat to bring with them to WDW.
I also give them each an over sized zip lock sandwhich bag to keep in their buckets and they use the bag for whatever they collect at WDW, such as stickers, pins, jewlery, drink stirers, napkins,,,,,,,
We bring the sand buckets in our suitcases - they are filled with socks or undies to make better use of the space in our suitcase. We ditch the sand bucket before we leave WDW.
Toothbrushes & toothpaste
DH does not like to leave it out in the bathroom.
We go to a McDolands, or any fast food place, which has the heavy duty
cardboard cup holder. I get plastic cups (could be Disney designed - I found some for $2 at our A&P food store) which fit into the cardboard cup holder.
Everyone gets a differnet color or pattern on their cups and they are placed into the 4 cup holder spots (enough space for your family of 4)
We place each of our toothbrushes in our designated cup. the toothpaste goes in the middle of the cardboard cup holder and the cardbaord cup holder with the cups holding our toothbrushes with the toothpaste(s) in the center goes on the top shelf of the closet.
In a moderate and a value there is no closet door - but my DH still feels the items which you use to place in your mouth is out of reach of any cleaning products and idle hands.
If there are no wall pegs (moderates have them) to hang your fanny packs, Nike nylon bags, & hats, then I would bring some CM removable hooks to use in the room, You can find removable hooks which hold at least 10 pounds in grocery and hardware stores. I think Walmart and Target well them too. I would use the hooks on the wall near the door. Great place for hats, bags and camera's to grab on the way out of your room.
Closets - use them to your jackets, sweatshirts, bulky shirts, shorts, pants - what ever you can hang.
In your WDW resort room your coset may only have 3 hangers. Not to fear.
While you shop for clothes during the year - ask the store if you could also keep the plastic hanger the item is hung on. Save about 20 of these plastic hangers to bring with you to WDW and use in your closet. No need to bring them home with you. You could either leave them in the closet or throw them away before you leave.
I hope the above is helpful