I'm so sorry for your loss. My dh and I had two completely normal, healthy pregnancies, and then four losses in a row...the last one being twins. It was hard, but going to see a miscarriage specialist really helped. After a whole lot of tests, he determined that my dh most likely had a gene that would cause us to miscarry 50% of our pregnancies, depending on whether or not the child we conceived had that gene. Science isn't good enough to tell you what the gene or the mutation is...only that it is "incompatible with life." Knowing that made our next pregnancy easier (there was nothing I could do to prevent a miscarriage from happening), and fortunately resulted in the birth of a healthy, baby boy. Best of luck to you and your wife with your future pregnancies. It's hard to conceive again because miscarriage is such a joy stealer, and early pregnancy now becomes a time of worry instead of celebration, but hang in there, almost every person who has a miscarriage goes on to have another healthy child. Even those of us who miscarried four times.