We prefer driving for a bunch of reasons.
1. It's cheaper. There are usually 4 of us, so gas and cheap hotel for one nite each way comes out far cheaper than 4 plane tickets, airport parking and rental car.
2. We can pack much more stuff. We usually rent a house or condo, or at least a suite with a kitchen. Driving lets us bring food, toys, and other stuff that we couldn't bring if we were flying.
3. Much more relaxing. We love to fly - not scared or anything - but the whole process is a huge hassle and wastes lots of time. We need to get to the airport 2 hours before our flight, deal with security, sit around doing nothing, spend 2 hours crammed into our seats, hassle with baggage claim and rental car crowds, and then do it all again when we head back home. When we drive, we are on our own schedule, stop when and where we want, eat well and arrive in Orlando rested and refreshed, not dragged out from flying.
4. Its educational. We've used the drives to teach our daughter map-reading skills. We've sampled regional specialty foods - pecan logs, Georgia peaches, pecans, free OJ in Florida, etc. We've driven through cotton fields, past areas that had recently burned in forest fires and through swampland - all opportunites to discuss stuff that never would come up if we were passing it at 30,000 feet.
Are there drawbacks to driving? The biggest one is the loss of time in Florida. We leave Saturday 8 am, stop for the nite in S. Carolina or Georgia around 9 pm. Then reach Orlando for a late lunch on Sunday. Had we flown, we would have had dinner in WDW on Saturday, so we do lose a day, but its worth it to us.
Steve