I've not done the November drive, but I can tell you that this past July, we hit some heavy rain driving through West Virginia. While it only slowed us down a bit, it caused me to think how a blast of snow, or freezing rain would really affect the drive. Diving home during March Break we hit the onset of a snow blast, but luckily we were already on the I90 an hour from Buffalo. I would plan out both routes, and keep a data plan on your phone for weather updates. Good luck!