Go to Tripadvisor.com
You'll see that the #1 (of 28) rated hotel in Lake City is Comfort Suites. Apparently it is about 6 months old and it has good reviews.
Hope that helps.... here are the other top ones they list:
Lake City Hotels with Similar Rankings
1. Comfort Suites Lake City
2. Hampton Inn and Suites Lake City 17 Reviews
Last reviewed Aug 1, 20091 mile W of Comfort Suites Lake City
3. Fairfield Inn 12 Reviews
Last reviewed Sep 22, 2009301 miles SE of Comfort Suites Lake City
4. Cabot Lodge 12 Reviews
Last reviewed Sep 13, 20091 mile W of Comfort Suites Lake City
5. Jameson Inn of Lake City 13 Reviews
Last reviewed Sep 25, 20091 mile W of Comfort Suites Lake City
6. Country Inn & Suites By Carlson Lake City 16 Reviews
Last reviewed Aug 15, 20091 mile W of Comfort Suites Lake City