We drive each year, leaving from London at 5 am on Friday morning. This gets us to Cincinnati around noon which has not been a problem. Knoxville TN at afternoon rush hour can be a pain but is better than the GTA (Toronto). We try to get to Calhoun GA, just north of Atlanta. We leave again on Sat at 5 am which means we go through Atlanta around 6:30 am. We stay in the HOV lanes too, it is less busy and not so many crazy lane changers! We arrive at Disney hotel around 1 pm, depending how long we doddle over breakfast and lunch and how long the stop is at the FLA-GA border, we always stop to get an orange juice and take a photo! My advice is to buy the "Along I 75 book". It is a great resource and full of neat info. It is very easy to use and there are lots of tid bits to read aloud to keep the kids amused. It is a great source of restaurant, gas and hotels along the way. We have 5 kids. Started driving to Disney when the youngest was 4, he is now 25, we've driven a lot! They fought a little long the way but did sleep a lot. We played all those road travelling games, finding the licence plates from each state and province etc. As they got older, they took over the "book" and looked forward to finding the cool things at the road side. Our favourite is the random dragon at the side of the road just past Caryville TN around mile marker 134. As the kids got older they were enthralled by the change in landscape, geology, flora and fauna too. We get kicks out of the change in temperature as we drive south too. Hope this helps! Andrea