Directionally, I-275 and I-4 are pretty easy as described above. Stay clear of the Veterans Expressway to the west and north of Tampa Airport (FL 589) - this is a tollway that is toll-by-plate only and you will get a bill in the mail for using it. Just be sure if you are using FL 60 to and from Clearwater to stay south toward Tampa and I-275.
I do want to warn you about the "easy" part of your question. Sunday morning is likely to be easiest in terms of when you drive. But I-275 in Tampa is often congested and adds time if you do not use detours like Hillsborough Ave. And I-4 from Tampa to Daytona is one of the most congested Interstates in the country, often with heavy traffic, "rubberbanding" slowdowns, and accidents/breakdowns along the shoulders. Leave a super long following distance in front of you and stay alert! (Don't forget I-4 is under construction through downtown Orlando and is often stop-and-go from Lake Buena Vista up to Maitland.)