I won't drive from Missouri to Florida, and that is 1/2 the distance!
If you could plot it out to hit sites we Disers could recommend, it might be fun, but if you have kids, I would not subject yourself to such torture!
BTW when are you going? Snow would be your biggest flight delay, it can cause a domino effect, so if you will be here in January or Feb, you might experience problems if connecting flights are anywhere north, which can happen. A direct flight to Las Vegas from Florida might only be delayed if it is mid winter, there is a storm and your plane is coming from Minneapolis or something. Hurricaines are also a big problem in Florida, so June-November there is a chance of problems. We are Americans, so it might be easier, but we usually get through security in Orlando two hours ahead and have time to eat before boarding.