The armrests in the bulkhead row do not lift. For that reason it can be a problem installing a carseat there. Also, you have no underseat storage in that row; everything must go in the overhead, which is a a problem if you get turbulence b/c you won't be able to get into your carryon bag for snacks/entertainment for baby.
We always board early and head for the back. With a carseat we are always off last, anyway, so that way we are out of others' way. The trick is carrying on the seat without hitting anyone. The best way to do that is to carry it high, upside down and sideways. (Think of the profile of the number 7.)
Note that you cannot sit in the rows immediately in front of or behind the exit row; those are restricted against carseats, too.
I find that the most important issue is which side of the plane I am on. Remember that you will be groping around behind the seat against the side bulkhead wall in order to install the seat. I'm right-handed, and I find that it seems to be easier for me to install the seat on the starboard side, because facing it, my right hand is in a better position to reach under it. It's harder on the port side where I have to reach under with my left hand. (Note that it is almost always easier for a woman to install a carseat on an airplane, because we are usually shorter and have smaller hands/arms. A tall person will have more trouble bending as far as needed in the cramped space.)