What price range are you looking at?
There are some very nice hotels just across the bay in Tampa, only about a 10 or 15 minute drive.
Marriot on Westshore, Wyndham on Kennedy and Westshore. Both are very nice.
There are also your standard Econolodge types on Rt. 19 in Clearwater.
The Don CeSar is a very, very nice hotel/resort. Can't miss it, it's pink.