Where are you traveling to, and how far home do you want to get before stopping?
Your post said SC in the title, but then you were talking about GA in your post - that's why I didn't answer - I couldn't figure out where you were trying to stop. (I see now you said Savannah and see on the map that's almost SC - didn't realize that until I looked at the map.)
When we stop overnight, it's always in SC because that's about 1/2 way for us. I couldn't imagine stopping in GA, because it seems so close to FL. But that is obviously dependent on how far you are traveling.
We have stayed numerous times at:
Best Western Executive Inn in Latta, SC.
and some others I can't remember right now.
On our upcoming trip, we will be staying:
Comfort Suites, Florence, SC which got a lot of good reviews on TripAdvisor.
and
Country Inns & Suites, Florence, SC - we like the Country Inns chain.