I had a 1999 VW Jetta that I bought new and put over 300,000 miles on.I used to do theme park trips to Disney and other parks as often as once every 2-3 weeks which is a 450-500 mile round trip for me.I still go with my current car a lot but not as often and when I go I stay longer.That Jetta however was the best car ever,it never left me stranded and I only spent over $400 one time at the mechanic.I changed the oil religiously every 5-6,000 miles and just kept an eye on it.When it was newer I took it on several trips of 1,000 plus miles, but once it got close to 200,000 miles I would definitely think about it if I should do those longer trips which eventually I decided was probably not the best idea,I would still do some 500 mile round trips to Orlando but I wasn't going to take it to Ohio or New York.So my response is as long as the car is in good shape and well maintained I would have no issue taking it on long trips with as many as 200,000 miles,after that just make sure you have good road service just in case.That Jetta's transmission went out about a year ago,but having the car about 10 years putting an average of 30,000 miles a year is a definite win.