Well can't speak for men but my dentist of all people told me that I'm immune to novicane (sp?) now because the chemical makeup of my body changed after having babies. I always had motion sickness going on spinny rides but could do any coaster no problem, well not anymore, now the coasters get me sick too. Can't take that stopping going from 60 to 0. I wore a patch behind my ear on our last trip to disney and could ride everything no problem, didn't even try mission space though. My daughter who was 7 at the time, gets motion sickness too so we got her chewable bonine and that worked for her on all the rides, didn't get sick once. TaraPA you can get Bonine at the drug store.