Or if you prefer not to do I-4, you can go out Hotel Plaza Bl, turn left at 535 (Crossroads shopping area), turn right at Palm Parkway (about 1 block), Palm Pkwy becomes Turkey Lake Road. Whole Foods will be on the right just before Sand Lake Rd.
From Mapquest:
via I-4: 8 miles, 16 minutes
via Palm Pkwy/Turkey Lake Rd: 7 miles, 16 minutes