The closest Whole Foods is just north of the Sand lake rd. exit off I-4,closer to Universal and the International Drive area than Disney.If you're coming from the Disney area either take I-4 to the Sand Lake rd exit and turn left or take Apopka Vineland rd north to Sand lake rd and make a right turn.Apopka Vineland is the road by the Disney Hotel Plaza blvd.entrance in Lake Buena Vista.