This is a story of frustration that actually has a happy ending... For years now I have been treated for Irritable Bowel Syndrom. I actually suffered from lower GI symptoms (undiagnosed) for as long as I can remember. When I was 23, a PA finally payed attention when I started losing weight and was unable to make it through a meal without having incapacitating diahrrea. At the time, my life was pretty stressful as I was working full time in one city and going to school full time in another cit an hour away. But my symptoms could no longer be explained mearly by stress, so the PA diagnosed IBS and prescribed medicine. The meds worked for a while, but I had to keep increasing the dose and finally the meds didn't work any more. The symptoms mysteriously disappeared after a course of antibiotics for a bacterial infection. Then they reappeared a couple months later, but were mild. However, after a while, I was unable to complete meals and losing weight again. I had since switched doctors. The new doctor prescibed a different IBS med. It worked for a while - maybe 6 months, but then my symptoms returned. At this point I was 29. I had been treated for IBS for 6 years with no diagnostic testing to rule out anything else. I tried to ignore the symptoms. I had done lots of research online to find some relief. I tried just about every diet imaginable for IBS thinking that perhaps a specific food was triggering my symptoms. But the only thing that worked even a little was eating small meals, eating VERY slowly and stopping prior to feeling full. I also wouldn't eat if I was going to be driving for any length of time, especially if I did not know where the bathrooms were along the way. The thing that bothered me most about the information that I could find regarding IBS is that, by definition, IBS means that there are physical symptoms in the absence of physiological abnormalities. So, unfortunately most people (including some of the doctors) interpret that to mean that IBS is a psychological thing that is affected by stress and emotions. So, I really wasn't that anxious to return to the doctor when my symptoms started getting worse. Then my symptoms changed. I started vomitting this really nasty (OK all vomit is nasty, but this was particularly bad) greyish substance. It didn't look or smell like anything I had ever seen before. (I work in emergency medicine, so I've seen every type of vomit imaginable.) And the nausea that accompanied this was so bad that I couldn't even move my head without dry-heaving. After the 3rd episode I was scared. So I went to the doctor and was immediately referred to a Gastroenterologist. After 6 years, I was finally referred to a specialist and was finally getting some diagnositc tests! After undergoing every type of imaging imaginable, they discovered that my esophogus does not connect properly to my stomach, half of my stomach was not working properly and part of my intestine didn't work properly. I was put on a couple of medications, and told to eat small meals through out the day. My symptoms improved for a while, but I was still having diahrrea. So the PA at the GI specialist's office told me to eat a high fiber diet. I didn't do a great job sticking to it, and my symptoms started becoming more frequent. I decided that I'd better get with the diet before my 6 month follow-up. So, with about 12 weeks to get myself together so that I wouldn't get scolded at the doctor's office, I started doing exactly what I'd been told to do. I was eating high fiber cereal every morning, eating fresh fruits and veggies, I had switched to whole grain bread and pasta. And the abdominal pain and nausea continued to increase. It got so bad that I was routinely having trouble getting up in the morning because I would wake up and develop abdominal pain and nausea that prevented me from getting out of bed for anywhere from 1/2 hour to an hour. Then the pain started waking me up - at first just in the morning, then throughout the night. I was having a hard time at work because if I ate, I'd get really nauseated and have bad abdominal pain, and if I didn't eat I'd feel lousy from not eating. I ended up calling my specialist to move up my appointment date after 3 nights of lying awake all night in pain. At my appointment, I saw a new PA. I told her about the pain, nausea and that I'd lost 10 pounds in 10 weeks because I couln't eat. I was diagnosed with Gastroparesis and put on an additional medication. It turns out that the high fiber diet that I'd been on to prevent the diahrrea is the worst thing in the world for Gastroparesis. So, now I'm on a high fat low fiber diet (eating all the food that was forbidden before.) The new med seems to be working pretty well. I have actually had 3 days in a row with no pain or nausea. After 10 weeks of constant pain and nausea, this is HUGE! I had a small set-back when I missed a dose of medicine, but nothing like before. The moral of my long story, it turned out that the problem actually was physiological. The doctors didn't know that until they actually looked. So, my diagnosis of IBS was truely a mis-diagnosis. If you don't feel good and/or your treatments are not working, get a second opinion. Just because the doctor can't find a physiological problem the first time (or never looks to begin with) does not mean that one does not exist.