Last year we took 3 trips. Drove once and flew twice. All depends on the nature and duration of the trip. In May we camped at Ft Wilderness and took 3 days to drive including a stay with relatives in Atlanta.
For Oct we also stayed a week but flew and flew in Dec for a 3 night stay. For a longer trip I actually don't mind the drive. We take lots of breaks to shop and have dinner it's part of the vacation. Dh and I share the driving.
For flying it's always Buffalo. We're in Burlington so it's super close and my IL's live in Pt Colborne. Last 2 trips we stayed at their house for our early morning flight.