We are a family of 5 and we alternate between 4B on Deck 8 forward, and 10C on Deck 1 midship, depending on itinerary. We have booked the same set of connecting 10Cs on Deck 1 three times now (specifically 1051 and 1053, under the midship stairs). We really like it, because the inside rooms are all the same, so it's not different in that regard. It's super quiet, because no one has has a reason to go down the hallway ever unless they are staying there. It can make getting off the ship and returning to your room from port very easy, because you don't have to wait for an elevator. Our midship rooms are very convenient to the lobby: up 2 flights of stairs and you are there. For higher decks, you can always find an uncrowded elevator on Deck 1.
You specifically asked about cons: I don't see any. It's just as convenient and quiet as our other rooms. If you are doing an ocean view, they have the smaller windows, instead of the bigger ones, but for insides, I don't think there's a down side.