We fly in and out of Sanford quite often depending on airfare and have done one way rentals many many times. Other than taking a little time out of your day it works pretty slick. I usually use Dollar because they have a location at the Wyndham near DTD. I just take a DTD bus and walk over to the Wyndham. I can usually get an economy car for around $25 and then maybe have to put $10 in gas in before dropping it off.