Well, that's one reason I did a reduction of my collection about a year ago. I got rid of shirts that really had no meaning to me. Most of my collection was gotten under the "rule" that it couldn't cost more than $5.00 and/or was a special place/event I'd attended. My mom & sister used to get me shirts that they thought I should have, so many of those were donated, since they still had plenty of wear.
I have a pretty large closet where we've put in 2 small dressers (each can hold 64 shirts), plus a small, full size dresser in the corner between my bed and closet (holds 176 shirts). Allowing for 3 or 4 in the laundry at any given time, there's just enough space.
And, I've stopped collecting t-shirts. Unless it's something R-E-A-L-L-L-L-L-Y special.