For east coast drivers, crossing west to I-75 and 429 is not trivial, but the FL 417 alternate route is trivial.
From Jacksonville, getting to WDW the I-75 and 429 way is about 3hrs 15min, going the I-4 and 417 way is about 2 hrs 55min. Time is not that far apart, but you make a number of road changes the west way.
(But I-75 and 429 are great for those coming from the West, central or Midwest!)