I live near the Sanford airport. I have never had trouble getting an Uber or Lyft from the Sanford area at that time of night. I'm not aware of any hotels near there that have a shuttle, but you could try contacting them. I've stayed (and recommend) the Hampton Inn in Lake Mary. There's also a Westin (listed as North Orlando), a Marriott, Marriott Courtyard or Residents Inn, and a Hyatt Place in Lake Mary. They are all in nice locations, about 8 miles from the airport. I haven't stayed in those, so I can't vouch for their interiors. I can't recall any hotels closer to the Sanford airport (which is weird now that I think about it). But I recommend staying in Lake Mary rather than Sanford. It's a much nicer location, closer to Disney, and not too much further from the airport. Now that I say that, I do think there is a hotel behind the Wawa on Rt. 46. It's not picturesque, but maybe they have a shuttle. Can't recall the name.