Cheyenne much nicer to look at from the outside but the Santa Fe has lovely newly refurbed rooms and got to be honest last time I stayed at Cheyenne, 2010, I thought it all looked a bit tired and it';s one of my favourite hotels.
There's nothing to choose between the 2 regards facilities, location, shuttle buses, etc.
Cheyenne has a launderette if you need one !
I had a bit of an issue with breakfast and ridiculously long queues at Santa Fe, but I think we were just unlucky, other than that I really enjoyed our stay there last year.
Most likely sleeping arrangement in the room will be 2 double beds at Santa Fe or a double and bunks at Cheyenne.
Haven't eaten at the restaurants so can't comment on those.
The only other thing I've noticed being mentioned more and more is the amount of school groups that use Cheyenne and their behaviour, certainly when we were there last January there were loads of teenage groups, a colleagues daughter was one of them and I was kind of glad we'd chosen Santa Fe.
All things considered I think I'd probably opt for Santa Fe for your trip.
