My cousins came out here for a two-week visit from Spain last year, and this is basically what we did
Day 1 - arrive
Day 2 - Disneyland
Day 3 - Drive to Monterey (took Hwy 5 & then cut away to Hwy 101)
Day 4 - Spent day at Monterey Bay Aquarium, Cannery Row, & ate dinner at an Irish pub
Day 5 - Went on 17-Mile Drive, then drove to San Francisco via Hwy 101, visited Pier 39
Day 6 - Went to Napa Valley for some wine tasting & olive oil tasting, evening went to Ghiradelli Square & ended at another little corner pub
Day 7 - Took cable car to Union Square & went shopping, drove to Yosemite & stayed at Redwoods in Yosemite
Day 8 - Visited Glacier Point and valley sightseeing, went back to cabin & had a nice dinner & relaxed
Day 9 - Headed home (Los Angeles) via Sequoia - stopped at Hume Lake (got there around noon) and spent a couple of hours (they swam), then went to Giant Forest & saw General Sherman (largest living thing in the world), and drove under the tunnel tree, then went home (Got home around 1:30am)
Day 10 - rested, washed clothes, hung out at home & went out to eat at Redondo Beach
Day 11 - Headed to Grand Canyon & stayed in town called Tuscayan 2 miles from south rim
Day 12 - Did an all-day River/Canyon experience, which included plane ride from Grand Canyon airport to Lake Powell/Page Airport, tour of the Antelope Canyon on Navajo land, trip to base of Glen Canyon dam for a 4-hour pontoon raft ride down a calm Colorado River (2 stops, 1 with petroglyphs, lunch along the river), and then a bus ride back to the Grand Canyon Airport
Day 13 - Drive to south rim to overlook the Grand Canyon. (We didn't have time to take the free shuttles to the other vistas along the south rim). Then drive to the West Rim of the Grand Canyon (maybe a 3-4 hour drive). Go to the Grand Canyon Skywalk (glass floor) on the Hualapai Indian Nation. Then stop at the Grand Canyon West Ranch overnight
Day 14 - Drive home (around 7 hours) and relax
Days 15 & 16 were hang out at the house & make homemade sangria (hey, they're from Spain!), shopping etc.
It was pretty busy, but a lot of fun.
Just make sure on your 2-week trip you have some rest-time built in
