There's a trolley stop at Fashion Valley, so that makes it pretty easy if you want to get downtown without having to drive (and park!).
Hmm...Fashion Valley is mostly filled with chain restaurants like Cheesecake Factory and Pizzeria Uno, and there's a P.F. Chang's along the edge of the Mall.
There's a local chain in the food court there - it's called Rubio's, and it's known for its fish tacos, though they have carne asada, chicken, and carnitas, too.
A couple of miles from Fashion Valley is a place called Forever Fondue where you can do a three-course fondue dinner - cheese fondue, meat/veggies/seafood cooked in broth, and chocolate fondue. It's pricey (~$40/person) but a lot of fun.
There's a really good breakfast place called Ricky's - it on the other side of the freeway from the Town & Country, and about a mile west.
Over on the edge of the other mall that's across the freeway (Mission Valley) there's a Mimi's Cafe, Karl Strauss Brewing Company, Fuddrucker's and a Chevy's.