I travel with my laptop everywhere I go and have never, EVER, had a problem. My parents even travel with their whole work stations... (Double monitors (laptop + extra monitor), mouses printers.. It's crazy and what I have to look forward to when I take over the business.. YAY...
And I ramble.
Onsite hotels I usually leave it out on the deck with no second thought. Off-site hotels depending on "shady scale" I put it in my case hidden in or under something, in the nightstand drawer, or in my suitcase.
But like I said, Universal rooms are very secure and very safe.