We have stayed at I95, exit 98, Santee, SC at Clark's Inn, a local, non-chain motel & have always had nice, clean rooms with friendly service. Clark's Restaurant is in front of the motel.
Also, there is a Maurice's bbq at the same exit - it just opened about two months ago - we ate there southbound & northbound - highly recommended it if you like bbq.
Further south on I95 we frequently stop at the Richmond Hills, GA or Darien, GA exits at the Hampton Inns - clean, friendly, safe, breakfast in the a.m., etc.
We haven't had the best of luck between Santee & northern GA.