We have driven it 3 times now from Hamilton. We usually leave around 6 or 7 pm just after grabbing a quick dinner. We drive straight through. We have driven down I75 through Detroit, as well as I79 through Pittsburgh, and I77 through Cleveland. I79 and I77 merge in Charleston, WV. My wife usually takes the first few hours. I drive the over nights and then she drives more once the sun comes up again. We typically have arrived around 4pm. Perfect for dinner at the resort and a good rest before the first day at the park!
We did drive down once where we left in the morning and found that by 8pm we were getting tired and needed a place to stay. I can't remember where we stayed but there's plenty of towns along the way to find hotels. Funny how driving over night doesn't make me as tired as driving all day. I guess it's the driving in the sun during the day that tires me out.
We prefer to drive as we go to the grocery store when there and get bagels, cereal, water and other breakfast items that we eat in our room before we go out for the day.