I used to unpack, but, as I've gotten more worried about bugs & other germs, we tend to live out of our suitcases.
When I pack, I pack by outfit & in the order we'll wear the outfits.
We start out neat, but, by the end of the trip, our suitcases are a jumbled mess which drives me crazy!
I bring large laundry bags, & our dirty clothes go in the bags in the closet. At the end of the trip, the dirty clothes & whatever clean clothes are left get divided into separate suitcases.
But, when I did unpack, I NEVER had room for all our clothes in the hotel room's drawers & closets anyway! And the drawers would become just as jumbled as the suitcases do. How do you fit 10 days worth of clothes for 5 people in 1 hotel room? (I fully admit I tend to overpack, & we normally have at least 2 outfits per person/day plus extra outfits.)
I do unpack the majority of our toiletries. And our shoes go in the closet.