It's a good way to see the floor of a reservation cost.
However, if I have a good idea where the Priceline/Hotwire hotel is I will look at hotel sites directly to see what they are charging.
If something ever goes wrong with a reservation or your hotel plans, you are far better booking directly from a hotel.
Over the years, the amount you save using these services has been eroded, so I suggest checking before going with the opaque sites.