I'd stay at a hotel in the southside/mandarin area. 103rd st area is not very safe anymore--I grew up there but things have unfortunately changed a lot since then. Another choice I'd recommend is Country Inn and Suites at Blanding and 295. That is close to your relatives but in a better area, is an inside corridor hotel, and is right by the highway so you can get an easy start to Orlando.
Hope this helps!
Tessie