They are all enjoyable, sometimes they go a bit too crass, but. comedy is meant to push the line.
When they get into overly detailed scatological humor is where I get tired, I think its just lazy.
I can watch clips of Family Guy for hours on youtube.
American Dad is OK but I am not a big fan of it, probably need to watch it more.
South park can be amazingly good, but sometimes its just filling time.
I think Rick and Morty, Futurama and Solar Opposites are really good as well.