I've done that drive about 4 times now, and have found it to be very easy. Yes, it can get congested. But, the signage is very good and it's easy to decipher where you are going.
The one thing I will caution you on is this....the drivers in that area tend to zoom right along. I'm no pokey puppy, but man, those Tampa folks are in one heck of a hurry to get to their destinations. So, take your time, don't be intimidated by the 'natives', and watch out in all directions.