to DL from Fresno is ~4-4.5 hours depending on traffic. to fly, you would have to fly into LAX as John Wayne and Long Beach do not have direct to Fresno. a shuttle from LAX will take ~45 to 60 minutes. factor in arriving 60 minutes before departure and you are up to 2 hours already. flight time is ~60 to 70 minutes due to the dinky prop engine plane you will fly on. now you are up to 3 hours. factor in time from getting off the plane to your shuttle...15-20 more minutes. finally the fact that your trip is bound to a specific flight time. i would drive and have the comfort and luxury of setting your own time guidelines...time is money!!!
just my honest opinion worth about $.02