This...
@darnheather should be getting new cards for each Tuition Payment (or 2 cards per each Tuition payment).
Are you paying the $10,000 at one time or can you pay like $5000 at one time and $5000 in 3 months (to try and space out Chase Cards if going that way)
You have a lot of options for cards and can get some good SUB's. Do you have a Player 2 or just you getting cards?
I am on my last year of college tuition for my 2 kids. I always got a new card or cards B4 Tuition was due. Got a lot of Chase UR's that way (College did not take AMEX). So, make sure to see what cards the college will accept and then go from there.
I think the Chase CSP/CSR Double Dip would be good for 1 payment. Maybe Cap One Venture X for another partial payment or Chase Ink Biz Cards. Or SW Cards or United Biz. So many possibilities.