I think it is more about the parent's personality. Having kids on a car trip is noisy, in my experience, whether it is talking, laughing, or crying, little voices turn into HUGE voices in a small space for hours and hours. So if you are th kind of parent that can relax all the rules and go with the flow, and if you have a DVD player,or some such entertainment device, and if you do some of the driving at night, this is completely doable.
I've found that it is normally ME who is complaining by hour 14. I'm tired of turning around to pick up dropped toys and hand out drinks. My butt hurts. And I'm irritated by listening to the Mulan voices without seeing the picture. Ny voice hurts from reading storybooks. It just forces you to be mommy & daddy for 25 hours straight. The kids are THRILLED to have you completely at their disposal for that long.
At least that is our story. Perhaps others have different situations.