The theming is really different between the two.
POFQ is a smaller resort layout that is much quieter and more intimate IMO. The gardens at POFQ are gorgeous, and I loved strolling around there enjoying them. I also happen to love the interior decor at POFQ, and the beds are I think the best beds I've ever slept on in Disney property LOL. (Again, YMMV, I like my beds a certain level of firmness)
Of course, it's been a long time since I've stayed at CBR, and I don't know if they renovated their room interiors since then. CBR is ginormous though! It's the biggest of the moderates, and it's a very different vibe. I felt like there were a lot more children there, but it could be just an illusion 'cause of how huge the resort is.
Besides, I'm partial to Coronado Springs (CSR). Not to confuse you more, but I think CSR has the most gorgeous lake and walkways around the lake. It's a little smaller than CBR but it still has aspects of a tropical beachy theme. (More spanish/mexican though, versus caribbean).
I've got most of my wedding guests booked at CSR + POFQ 'cause they're my two favorite resorts other than the DVC resorts. The moderates just have an amazing level of detail and beauty when it comes to their landscaping. I've never felt the deluxes' landscaping can match up.