Yes, as in Kingston upon Hull, Yorkshire. One of my best friends grew up there. They have a very recognisable accent and it was the birthplace of William Wilberforce and Amy Johnston.
Now I could be ‘difficult’ but I am going to offer an easy one.
Dylan Thomas lived in Laugharne. It is thought to be his inspiration for the fictional Llareggub in Under Milkwood.
Mesilla .... No, I haven’t heard of it.