Yep! There is a former marine base about 3/4 of a mile from my house. The hangars there have been used to film parts of Pearl Harbor and Austin Powers: The Spy Who Shagged Me. Scenes from The Haunting were filmed at an architecture firm in my town, Tustin. The Orange Traffic Circle has been used to film movies like That Thing You Do! and Clockstoppers, and also Orange was used to film parts of Big Momma's House, Rocky and Bullwinkle, and a lot of other movies. Scenes from The Fast and the Furious were filmed in Little Saigon. Legally Blonde and Evolution filmed at the old Santa Ana courthouse.
There have been tons of movies filmed in Orange County. And of course, if you go to the LA area, you will almost always see something filming if you drive around enough.