Not sure about best room, but you could request close to lobby, elevators, high/low floor, etc. You could also look thru room assignments & see what other peeps have to say about their room/stay.
We absoultely LOVE HRH!!!

We thought about trying PBH this time around and just pool hopping to HRH, but we spend so much time at the pool that it was really a higher priority than trying something different. The whole vibe of the place is amazing. From the pool, rooms, grounds, food, closeness to parks, etc., it's hard to beat, (for us). We have two boys ages 11 & 13, so this hotel is the best fit for our family.
For some reason, for me to get the "Stay more, play more" discount to come up, I have to litererally google that specific discount. If I just go to the Loews site and look at discounts, this one doesn't come up.
And yeah, the pool Rocks!!! Huge water slide that is open and twists, underwater music, sandy beach, hot tubs, cabanas, activities/dive-in movies, etc. The staff was super friendly and very accomidating with requests and answering a plethera of questions we had. Just super!!!
