First question: Which Grand Canyon do you plan to visit? You have four choices, and they are quite different. Realistically, you have to choose -- they are not close together:
Southern Rim -- This is the most popular portion -- the most popular option by far. Plenty of hotels, both inside and outside the national park. Lots of restaurants, shops, museums. Look up the ranger programs ahead of time. And LOTS of people. If you're going during the summer, you'll need to make reservations yesterday -- seriously, hotels fill up fast. If you want to ride mules, you should reserve that immediately too. And because it's so crowded, you won't be allowed to drive your own car within the park, but busses are available.
Northern Rim -- Much less crowded, about 10 degrees cooler at all times, and open only during prime season. This area is much, much smaller and more remote. You'll find only the Grand Canyon Lodge, which is absolutely lovely, and a collection of little cabins that look like a Lincoln Log village. You'll find only one nice restaurant, one pizza/deli, and one bar -- but you'll also miss the crowds. You'll have access to ranger programs, and they offer a corny-but-fun cookout that includes a train ride. Just like the Southern Rim, you need to make reservations now.
Phantom Ranch -- This hike-in /mule-in cabin camp is located at the foot of the canyon. You need reservations well in advance, but you don't need to bring much: You'll have a bed and food provided to you. It's an all-day ride or a serious hike, but you'll be in a portion of the canyon that few ever see. I believe trips to Phantom Ranch originate from the Southern Rim only.
Western Rim -- Unlike the others, this is not part of the national parks; rather, this is owned by the Havasupi indian tribe. You may've seen the Sky Bridge (do I have that name right?) on the news; they spend millions for this glass bridge so you can feel like you're standing in mid-air over the canyon. Walking on it is very expensive. Their nicest facilities are all at the bottom of the canyon, so you must be in good enough shape to make the walk -- or you can hire a ride on a mule, or -- if your pockets are deep enough -- on a helicoptor. They have only one hotel, but they have waterfalls and swimming areas that are wonderful.