We've been on five Disney cruises and never eaten at Palo. Do I regret that? No, not at all. When our son was with us we enjoyed mealtimes together and honestly never even considered Palo. Our last cruise was just my husband and I as our son is now in college. I did try to book Palo brunch ahead of time, but it was sold out by the time silvers could book. We talked about trying to book on board, but when we saw the line we just looked at each other and said, meh, who cares? We went on with our day and had a wonderful cruise.
Now, I guess to be fair I should that add we live in an area with tons of people of Italian heritage. There are wonderful authentic italian restaurants on every corner it seems, so going out of our way (and paying extra) for Italian food isn't really a big draw for us when we are vacation. We have always enjoyed the MDR experiences, anyway. Maybe someday we will try Palo now that our son can go. Who knows? But "regret" not going so far? Nope!