Every year we stay 3-4 days at a moderate (POFQ our favorite) and then we spend another 8 days at a deluxe (Animal Kingdom Lodge for the last three years). We like both resorts. I think it depends on what you are after. If you are not going to spend any time at the resort, or very little, I would opt for the moderate -- for us POFQ. We like the food court and the fact that it is the smallest of the moderates gives it a quaint feeling. We also like the theme and the proximity to DTD is really nice with the boat ride.
Since we've been so many times, we spend a lot of time at the hotel when we move to the deluxe. At AKL there are lots of kids activities and we enjoy both Boma and Mara. Have not eaten at Jikos. This year we are staying concierge so plan to spend "eating" times more at the hotel and hang out. The other things that I really like about the deluxe properties are the fact that they have queen beds, rooms are a bit larger, they have balconies that you can sit on and enjoy the outside, they have room service -- if you want it, and the lobbies seem much grander and offer a very comfortable place to just hang out. Some really enjoy the indoor corridors and the "closet" but for us neither is a big deal.
The similarities are this -- the moderate and deluxe (at least AKL) both have food courts, they both have double sinks, refrigerators and hair dryers. Housekeeping has been about the same at both resorts and we have gotten good as well as bad service at both levels. Since we stay at AKL there isn't another source of transportation and we don't mind the buses.
If money isn't an issue I would probably stay at the deluxe. But, if you spend a great deal of time at the parks and outside the room/resort property then I would opt for the moderate. When we go in the spring we always stay at the moderate.