I live in Charleston, and frequently have to go to HH for work. It is about 2 hours to the resort from the airport. It's not a difficult drive. Be careful when driving on 17 South. It's a one lane road inhabited by semi's and bad drivers (all roads in SC are inhabited by bad drivers), so the state police has posted extra officers on the road, and they are nabbing speeders left and right.
Enjoy the Palmetto State!!!